Journal of the American Society of Echocardiography
Volume 14, Issue 8 , Pages 773-781 , August 2001

Assessment of no-reflow phenomenon after acute myocardial infarction with harmonic angiography and intravenous pump infusion with Levovist: Comparison with intracoronary contrast injection

References 

  1. Gibson M, Cannon CP, Murphy SA, Ryan KA, Mesley R, Marble SJ, et al.  Relationship of TIMI myocardial perfusion grade to mortality after administration of thrombolytic drugs. Circulation. 2000;101:125–130
  2. Ito H, Tomooka T, Sakai N, Yu H, Higashino Y, Fujii K, et al.  Lack of myocardial perfusion immediately after successful thrombolysis: a predictor of poor recovery of left ventricular function in anterior myocardial infarction. Circulation. 1992;85:1699–1705
  3. Kondo M, Nakano A, Saito D, Shimono Y. Assessment of microvascular no-reflow phenomenon using technetium-99m macroaggregated albumin scintigraphy in patients with acute myocardial infarction. J Am Coll Cardiol. 1998;32:898–903
  4. Wu KC, Kim RJ, Bluemke DA, Rochitte CE, Zerhouni EA, Becker LC, et al.  Quantification and time course of microvascular obstruction by contrast-enhanced echocardiography and magnetic resonance following acute myocardial infarction and reperfusion. J Am Coll Cardiol. 1998;32:1756–1764
  5. Agati L, Voci P, Bilotta F, Luongo R, Autore C, Penco M, et al.  Influence of residual perfusion within the infarct zone on the natural history of left ventricular dysfunction after acute myocardial infarction: a myocardial contrast echocardiographic study. J Am Coll Cardiol. 1994;24:336–342
  6. Agati L, Voci P, Hickle P, Vizza DC, Autore C, Fedele F, et al.  Tissue-type plasminogen activator therapy versus primary coronary angioplasty: impact on myocardial tissue perfusion and regional function 1 month after uncomplicated myocardial infarction. J Am Coll Cardiol. 1998;31:338–343
  7. Jayaweera AR, Edwards N, Glasheen WP, Villaneuva FS, Abbott RD, Kaul S. In vivo myocardial kinetics of air-filled albumin microbubbles during myocardial contrast echocardiography: comparison with radiolabeled red blood cells. Circ Res. 1994;74:1157–1165
  8. Firschke C, Lindner JR, Wei K, Goodman NC, Skyba DM, Kaul S. Myocardial perfusion imaging in the setting of coronary stenosis and acute myocardial infarction using venous injection of a second-generation echocardiographic contrast agent. Circulation. 1997;96:959–967
  9. Porter TR, Xie F, Kricsfeld D, Ambruster RW. Improved myocardial contrast with second harmonic transient response imaging in humans using intravenous perfluorcarbon-exposed sonicated dextrose albumin. J Am Coll Cardiol. 1996;27:1497–1501
  10. Wei K, Jayaweera A, Firoozan S, Linka A, Skyba D, Kaul S. Quantification of myocardial blood flow with ultrasound-induced destruction of microbubbles administered as a continuous venous infusion. Circulation. 1998;97:473–483
  11. Kaul S, Senior R, Dittrich H, Raval U, Khatter R, Lahiri A. Detection of coronary artery disease with myocardial contrast echocardiography: comparison with 99m Tc-sestamibi single photon emission tomography. Circulation. 1997;96:785–792
  12. Burns PN, Powers JE, Hope Simpson D, Brezina A, Kolin A, Chin CT. Harmonic power mode Doppler using microbubble contrast agents: an improved method for small vessel flow imaging. Proc IEEE UFFC. 1995;1547–1550
  13. Burns PN, Wilson SR, Muradali D, Powers JE, Fritzsch T. Intermittent US harmonic contrast enhanced imaging and Doppler improves sensitivity and longevity of small vessel detection. Radiology. 1996;201:159–163
  14. Becher H, Tiemann K, Schlief R, Luderitz B, Nanda C. Harmonic power Doppler contrast echocardiography: preliminary clinical results. Echocardiography. 1997;14:637–642
  15. Irvine T, Wanitkun S, Powers J, Shiota T, Kenny A, Sahn DJ. Acoustically stimulated transient power scattering explains enhanced detection of the very low velocities in myocardial capillaries by power Doppler imaging: an in vitro study. J Am Soc Echocardiogr. 1999;12:643–649
  16. Arruda AM, Dearani JA, Click RL, Ishikura F, Seward JB. Intraoperative application of power Doppler imaging: visualization of myocardial perfusion after anastomosis of left internal thoracic artery to left anterior descending coronary artery. J Am Soc Echocardiogr. 1999;12:650–654
  17. Porter TR, Li S, Oster R, Deligonul U. The clinical implications of no reflow demonstrated with intravenous perfluorcarbon containing microbubbles following restoration of Thrombolysis In Myocardial Infarction (TIMI 3) flow in patients with acute myocardial infarction. Am J Cardiol. 1998;82:1173–1177
  18. TIMI Study Group . The Thrombolysis In Myocardial Infarction (TIMI) trial: phase 1 findings. N Engl J Med. 1985;312:932–936
  19. Dagianti A, Rosanio S, Penco M, Dagianti A, Sciomer S, Tocchi M, et al.  Clinical and prognostic usefulness of supine bicycle exercise echocardiography in the functional evaluation of patients undergoing elective percutaneous transluminal angioplasty. Circulation. 1997;95:1176–1185
  20. Agati L, Voci P, Bilotta F, Luongo R, Iacoboni C, Fedele F, et al.  Dipyridamole myocardial contrast echocardiography in patients with single vessel coronary artery disease: perfusion, anatomic and functional correlates. Am Heart J. 1994;128:28–35
  21. Agati L, Voci P, Luongo R, Testa G, Autore C, Mallus MT, et al.  Combined use of dobutamine echocardiography and myocardial contrast echocardiography to predict recovery of regional dysfunction after coronary revascularization in patients with recent myocardial infarction. Eur Heart J. 1997;18:771–779
  22. De Castro S, Agati L, Cartoni D, Papetti F, Beni S, Adorisio R, et al.  Harmonic imaging with Levovist for transthoracic 3D echo reconstruction of left ventricle in patients with post-ischemic left ventricular dysfunction and suboptimal acoustic windows. J Am Soc Echocardiogr. 2000;13:139–145
  23. Ito H, Maruyama A, Iwakura K, Takiuchi S, Masuyama T, Hori M, et al.  Clinical implications of the “no reflow” phenomenon: a predictor of complications and left ventricular remodeling in reperfused anterior wall myocardial infarction. Circulation. 1996;93:223–228
  24. Sakuma T, Hayashi Y, Sumii K, Imazu M, Yamakido M. Prediction of short- and intermediate-term prognoses of patients with acute myocardial infarction one day after recanalization. J Am Coll Cardiol. 1998;32:890–897
  25. Senior R, Kaul S, Soman P, Lahiri A. Power Doppler harmonic imaging: a feasibility study of a new technique for the assessment of myocardial perfusion. Am Heart J. 2000;139:245–251
  26. Heinle SK, Noblim J, Goree-Best P, Mello A, Ravad G, Mull S, et al.  Assessment of myocardial perfusion by harmonic power Doppler imaging at rest and during adenosine stress. Circulation. 2000;102:55–63
  27. Pelberg RA, Wei K, Kamiyama N, Sklenar J, Bin J, Kaul S. Potential advantage of flash echocardiography for digital subtraction of B-mode images acquired during myocardial contrast echocardiography. J Am Soc Echocardiogr. 1999;12:85–93
  28. Albrecht T, Urbank A, Mahler M, Bauer A, Dorè CJ, Blomley MJK, et al.  Prolongation and optimization of Doppler enhancement with a microbubble US contrast agent by using continuous infusion: preliminary experience. Radiology. 1998;207:339–347
  29. Agati L. Microvascular integrity after reperfusion therapy. Am Heart J. 1999;138:76–79
  30. Agati L, Autore C, Iacoboni C, Castaldo M, Veneroso G, Voci P, et al.  The complex relation between myocardial viability and functional recovery in chronic left ventricular dysfunction. Am J Cardiol. 1999;81(12A):33G–35G

 Reprint requests: Luciano Agati, MD, Echocardiography Laboratory, Department of Cardiology, “La Sapienza” University of Rome, Policlinico Umberto I, Viale del Policlinico, 155, 00161 Rome, Italy (E-mail: Luciano.Agati@uniroma1.it).

PII: S0894-7317(01)33932-9

Journal of the American Society of Echocardiography
Volume 14, Issue 8 , Pages 773-781 , August 2001