Journal of the American Society of Echocardiography
Volume 22, Issue 2 , Pages 190-197 , February 2009

Prognostic Value of Left Ventricular End-Systolic Volume Index as a Predictor of Heart Failure Hospitalization in Stable Coronary Artery Disease: Data from the Heart and Soul Study

  • David D. McManus, MD

      Affiliations

    • Division of Cardiology, University of California, San Francisco, California
    • Department of Medicine, University of California, San Francisco, California
    • D.D.M. and S.J.S. contributed equally to this work.
    • ,
  • Sanjiv J. Shah, MD

      Affiliations

    • Division of Cardiology, University of California, San Francisco, California
    • Department of Medicine, University of California, San Francisco, California
    • D.D.M. and S.J.S. contributed equally to this work.
    • ,
  • Mary Rose Fabi, MD

      Affiliations

    • Department of Medicine, Veterans Affairs Medical Center, San Francisco, California
    • ,
  • Alisa Rosen, MD

      Affiliations

    • Division of Cardiology, University of California, San Francisco, California
    • Department of Medicine, University of California, San Francisco, California
    • ,
  • Mary A. Whooley, MD

      Affiliations

    • Department of Medicine, University of California, San Francisco, California
    • Department of Medicine, Veterans Affairs Medical Center, San Francisco, California
    • ,
  • Nelson B. Schiller, MD

      Affiliations

    • Division of Cardiology, University of California, San Francisco, California
    • Department of Medicine, University of California, San Francisco, California
    • Department of Medicine, Veterans Affairs Medical Center, San Francisco, California
    • Corresponding Author InformationReprint requests: Nelson B. Schiller, MD, Division of Cardiology, Department of Medicine, University of California, San Francisco, 505 Parnassus Ave., San Francisco, CA 94143

References 

  1. Adams KF, Fonarow GC, Emerman CL, LeJemtel TH, Costanzo MR, Abraham WT, et al. Characteristics and outcomes of patients hospitalized for heart failure in the United States: rationale, design, and preliminary observations from the first 100,000 cases in the Acute Decompensated Heart Failure National Registry (ADHERE). Am Heart J. 2005;149:209–216
  2. Gheorghiade M, Bonow RO. Chronic heart failure in the United States: a manifestation of coronary artery disease. Circulation. 1998;97:282–289
  3. Gheorghiade M, Ruzumna P, Borzak S, Havstad S, Ali A, Goldstein S. Decline in the rate of hospital mortality from acute myocardial infarction: impact of changing management strategies. Am Heart J. 1996;131:250–256
  4. Gheorghiade M, Sopko G, De Luca L, Velazquez EJ, Parker JD, Binkley PF, et al. Navigating the crossroads of coronary artery disease and heart failure. Circulation. 2006;114:1202–1213
  5. Migrino RQ, Young JB, Ellis SG, White HD, Lundergan CF, Miller DP, et al. End-systolic volume index at 90 to 180 minutes into reperfusion therapy for acute myocardial infarction is a strong predictor of early and late mortality (The Global Utilization of Streptokinase and t-PA for Occluded Coronary Arteries (GUSTO)-I Angiographic Investigators). Circulation. 1997;96:116–121
  6. White HD, Norris RM, Brown MA, Brandt PW, Whitlock RM, Wild CJ. Left ventricular end-systolic volume as the major determinant of survival after recovery from myocardial infarction. Circulation. 1987;76:44–51
  7. Kjoller-Hansen L, Steffensen R, Grande P. Beneficial effects of ramipril on left ventricular end-diastolic and end-systolic volume indexes after uncomplicated invasive revascularization are associated with a reduction in cardiac events in patients with moderately impaired left ventricular function and no clinical heart failure. J Am Coll Cardiol. 2001;37:1214–1220
  8. Hamer AW, Takayama M, Abraham KA, Roche AH, Kerr AR, Williams BF, et al. End-systolic volume and long-term survival after coronary artery bypass graft surgery in patients with impaired left ventricular function. Circulation. 1994;90:2899–2904
  9. Yamaguchi A, Ino T, Adachi H, Mizuhara A, Murata S, Kamio H. Left ventricular end-systolic volume index in patients with ischemic cardiomyopathy predicts postoperative ventricular function. Ann Thorac Surg. 1995;60:1059–1062
  10. Jessup M, Brozena S. Heart failure. N Engl J Med. 2003;348:2007–2018
  11. Hunt SA, Abraham WT, Chin MH, Feldman AM, Francis GS, Ganiats TG, et al. ACC/AHA 2005 Guideline Update for the Diagnosis and Management of Chronic Heart Failure in the Adult: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Update the 2001 Guidelines for the Evaluation and Management of Heart Failure). Circulation. 2005;112:e154–e235
  12. Lang RM, Bierig M, Devereux RB, Flachskampf FA, Foster E, Pellikka PA, et al. Recommendations for chamber quantification: a report from the American Society of Echocardiography's Guidelines and Standards Committee and the Chamber Quantification Writing Group, developed in conjunction with the European Association of Echocardiography, a branch of the European Society of Cardiology. J Am Soc Echocardiogr. 2005;18:1440–1463
  13. Vasan RS, Larson MG, Benjamin EJ, Evans JC, Levy D. Left ventricular dilatation and the risk of congestive heart failure in people without myocardial infarction. N Engl J Med. 1997;336:1350–1355
  14. Kirkpatrick JN, Vannan MA, Narula J, Lang RM. Echocardiography in heart failure: applications, utility, and new horizons. J Am Coll Cardiol. 2007;50:381–396
  15. Ruo B, Rumsfeld JS, Hlatky MA, Liu H, Browner WS, Whooley MA. Depressive symptoms and health-related quality of life: the Heart and Soul Study. JAMA. 2003;290:215–221
  16. Erbel R, Schweizer P, Lambertz H, Henn G, Meyer J, Krebs W, et al. Echoventriculography—a simultaneous analysis of two-dimensional echocardiography and cineventriculography. Circulation. 1983;67:205–215
  17. Folland ED, Parisi AF, Moynihan PF, Jones DR, Feldman CL, Tow DE. Assessment of left ventricular ejection fraction and volumes by real-time, two-dimensional echocardiography (A comparison of cineangiographic and radionuclide techniques). Circulation. 1979;60:760–766
  18. Greenberg PS, Berge RD, Johnson KD, Bible M, Ellestad MH, Hayes M, et al. Use of end-systolic volume changes with exercise to detect left ventricular dysfunction in patients with coronary artery disease. Clin Cardiol. 1982;5:409–414
  19. Parisi AF, Moynihan PF, Feldman CL, Folland ED. Approaches to determination of left ventricular volume and ejection fraction by real-time two-dimensional echocardiography. Clin Cardiol. 1979;2:257–263
  20. Schiller NB, Acquatella H, Ports TA, Drew D, Goerke J, Ringertz H, et al. Left ventricular volume from paired biplane two-dimensional echocardiography. Circulation. 1979;60:547–555
  21. Weiss JL, Eaton LW, Kallman CH, Maughan WL. Accuracy of volume determination by two-dimensional echocardiography: defining requirements under controlled conditions in the ejecting canine left ventricle. Circulation. 1983;67:889–895
  22. Wyatt HL, Meerbaum S, Heng MK, Gueret P, Corday E. Cross-sectional echocardiography (III. Analysis of mathematic models for quantifying volume of symmetric and asymmetric left ventricles). Am Heart J. 1980;100:821–828
  23. McKee PA, Castelli WP, McNamara PM, Kannel WB. The natural history of congestive heart failure: the Framingham study. N Engl J Med. 1971;285:1441–1446
  24. Redfield MM, Jacobsen SJ, Burnett JC, Mahoney DW, Bailey KR, Rodeheffer RJ. Burden of systolic and diastolic ventricular dysfunction in the community: appreciating the scope of the heart failure epidemic. JAMA. 2003;289:194–202
  25. Zoghbi WA, Enriquez-Sarano M, Foster E, Grayburn PA, Kraft CD, Levine RA, et al. Recommendations for evaluation of the severity of native valvular regurgitation with two-dimensional and Doppler echocardiography. J Am Soc Echocardiogr. 2003;16:777–802
  26. Gehi AK, Ali S, Na B, Schiller NB, Whooley MA. Inducible ischemia and the risk of recurrent cardiovascular events in outpatients with stable coronary heart disease: the heart and soul study. Arch Intern Med. 2008;168:1423–1428
  27. DeLong ER, DeLong DM, Clarke-Pearson DL. Comparing the areas under two or more correlated receiver operating characteristic curves: a nonparametric approach. Biometrics. 1988;44:837–845
  28. Brutsaert DL, De Keulenaer GW. Diastolic heart failure: a myth. Curr Opin Cardiol. 2006;21:240–248
  29. De Keulenaer GW, Brutsaert DL. Systolic and diastolic heart failure: different phenotypes of the same disease?. Eur J Heart Fail. 2007;9:136–143
  30. Petrie MC, Caruana L, Berry C, McMurray JJ. “Diastolic heart failure” or heart failure caused by subtle left ventricular systolic dysfunction?. Heart. 2002;87:29–31
  31. Burkhoff D, Mirsky I, Suga H. Assessment of systolic and diastolic ventricular properties via pressure-volume analysis: a guide for clinical, translational, and basic researchers. Am J Physiol Heart Circ Physiol. 2005;289:H501–H512
  32. Konstam MA. “Systolic and diastolic dysfunction” in heart failure? (Time for a new paradigm). J Card Fail. 2003;9:1–3
  33. Maurer MS, El Khoury Rumbarger L, King DL. Ventricular volume and length in hypertensive diastolic heart failure. J Am Soc Echocardiogr. 2005;18:1051–1057
  34. Bombardini T. Myocardial contractility in the echo lab: molecular, cellular and pathophysiological basis. Cardiovasc Ultrasound. 2005;3:27
  35. Sagawa K, Suga H, Shoukas AA, Bakalar KM. End-systolic pressure/volume ratio: a new index of ventricular contractility. Am J Cardiol. 1977;40:748–753
  36. Suga H. End-systolic pressure-volume relations. Circulation. 1979;59:419–420
  37. Suga H, Kitabatake A, Sagawa K. End-systolic pressure determines stroke volume from fixed end-diastolic volume in the isolated canine left ventricle under a constant contractile state. Circ Res. 1979;44:238–249
  38. St John Sutton M, Pfeffer MA, Plappert T, Rouleau JL, Moye LA, Dagenais GR, et al. Quantitative two-dimensional echocardiographic measurements are major predictors of adverse cardiovascular events after acute myocardial infarction (The protective effects of captopril). Circulation. 1994;89:68–75
  39. Burns RJ, Gibbons RJ, Yi Q, Roberts RS, Miller TD, Schaer GL, et al. The relationships of left ventricular ejection fraction, end-systolic volume index and infarct size to six-month mortality after hospital discharge following myocardial infarction treated by thrombolysis. J Am Coll Cardiol. 2002;39:30–36
  40. Norris RM, White HD, Cross DB, Wild CJ, Whitlock RM. Prognosis after recovery from myocardial infarction: the relative importance of cardiac dilatation and coronary stenoses. Eur Heart J. 1992;13:1611–1618
  41. Cleland JG, Daubert JC, Erdmann E, Freesmantle N, Gras D, Kappenberger L, et al. The effect of cardiac resynchronization on morbidity and mortality in heart failure. N Engl J Med. 2005;352:1539–1549
  42. Detaint D, Messika-Zeitoun D, Maalouf J, Tribouilloy C, Mahoney DW, Tajik AJ, et al. Quantitative echocardiographic determinants of clinical outcome in asymptomatic patients with aortic regurgitation: a prospective study. J Am Coll Cardiol. 2008;1:1–11
  43. Himelman RB, Cassidy MM, Landzberg JS, Schiller NB. Reproducibility of quantitative two-dimensional echocardiography. Am Heart J. 1988;115:425–431
  44. Kuecherer HF, Kee LL, Modin G, Cheitlin MD, Schiller NB. Echocardiography in serial evaluation of left ventricular systolic and diastolic function: importance of image acquisition, quantitation, and physiologic variability in clinical and investigational applications. J Am Soc Echocardiogr. 1991;4:203–214

 Conflicts of Interest: None.

 Financial Disclosures: The Heart and Soul Study was supported by grants from the Department of Veterans Affairs (Epidemiology Program), Robert Wood Johnson Foundation, American Federation for Aging Research, and National Institutes of Health (R01 HL079235). Dr Shah was supported by a Heart Failure Society of America Research Fellowship Award.

PII: S0894-7317(08)00663-9

doi: 10.1016/j.echo.2008.11.005

Journal of the American Society of Echocardiography
Volume 22, Issue 2 , Pages 190-197 , February 2009

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