Journal of the American Society of Echocardiography
Volume 22, Issue 7 , Pages 839-846 , July 2009

Mechanical Dyssynchrony Assessed by Speckle Tracking Imaging as a Reliable Predictor of Acute and Chronic Response to Cardiac Resynchronization Therapy

  • Yoshihiro Seo, MD

      Affiliations

    • Cardiovascular Division, Institute of Clinical Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki, Japan
    • Corresponding Author InformationReprint requests: Yoshihiro Seo, MD, Cardiovascular Division, Institute of Clinical Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba 305-8575, Japan.
    • ,
  • Tomoko Ishizu, MD

      Affiliations

    • Cardiovascular Division, Institute of Clinical Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki, Japan
    • ,
  • Fumiko Sakamaki, RDMS

      Affiliations

    • Cardiovascular Division, Institute of Clinical Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki, Japan
    • ,
  • Masayoshi Yamamoto, MD

      Affiliations

    • Cardiovascular Division, Institute of Clinical Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki, Japan
    • ,
  • Tomoko Machino, MD

      Affiliations

    • Cardiovascular Division, Institute of Clinical Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki, Japan
    • ,
  • Hiro Yamasaki, MD

      Affiliations

    • Cardiovascular Division, Institute of Clinical Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki, Japan
    • ,
  • Ryo Kawamura, MD

      Affiliations

    • Cardiovascular Division, Institute of Clinical Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki, Japan
    • ,
  • Kentaro Yoshida, MD

      Affiliations

    • Cardiovascular Division, Institute of Clinical Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki, Japan
    • ,
  • Yukio Sekiguchi, MD

      Affiliations

    • Cardiovascular Division, Institute of Clinical Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki, Japan
    • ,
  • Satoru Kawano, MD

      Affiliations

    • Cardiovascular Division, Institute of Clinical Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki, Japan
    • ,
  • Hiroshi Tada, MD

      Affiliations

    • Cardiovascular Division, Institute of Clinical Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki, Japan
    • ,
  • Shigeyuki Watanabe, MD

      Affiliations

    • Cardiovascular Division, Institute of Clinical Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki, Japan
    • ,
  • Kazutaka Aonuma, MD

      Affiliations

    • Cardiovascular Division, Institute of Clinical Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki, Japan

References 

  1. Mele D, Pasanisi G, Capasso F, De Simone A, Morales MA, Poggio D, et al. Left intraventricular myocardial deformation dyssynchrony identifies responders to cardiac resynchronization therapy in patients with heart failure. Eur Heart J. 2006;27:1070–1078
  2. Zwanenburg JJ, Götte MJ, Marcus JT, Kuijer JP, Knaapen P, Heethaar RM, et al. Propagation of onset and peak time of myocardial shortening in ischemic versus nonischemic cardiomyopathy: assessment by magnetic resonance imaging myocardial tagging. J Am Coll Cardiol. 2005;46:2215–2222
  3. Bleeker GB, Schalij MJ, Molhoek SG, Verwey HF, Holman ER, Boersma E, et al. Relationship between QRS duration and left ventricular dyssynchrony in patients with end-stage heart failure. J Cardiovasc Electrophysiol. 2004;15:544–549
  4. Ghio S, Constantin C, Klersy C, Serio A, Fontana A, Campana C, et al. Interventricular and intraventricular dyssynchrony are common in heart failure patients, regardless of QRS duration. Eur Heart J. 2004;25:571–578
  5. Pitzalis MV, Iacoviello M, Romito R, Massari F, Rizzon B, Luzzi G, et al. Cardiac resynchronization therapy tailored by echocardiographic evaluation of ventricular asynchrony. J Am Coll Cardiol. 2002;40:1615–1622
  6. Yu CM, Chau E, Sanderson JE, Fan K, Tang MO, Fung WH, et al. Tissue Doppler echocardiographic evidence of reverse remodeling and improved synchronicity by simultaneously delaying regional contraction after biventricular pacing therapy in heart failure. Circulation. 2002;105:438–445
  7. Sogaard P, Egeblad H, Kim WY, Jensen HK, Pedersen AK, Kristensen BO, et al. Tissue Doppler imaging predicts improved systolic performance and reversed left ventricular remodeling during long-term cardiac resynchronization therapy. J Am Coll Cardiol. 2002;40:723–730
  8. Nelson GS, Curry CW, Wyman BT, Kramer A, Declerck J, Talbot M, et al. Predictors of systolic augmentation from left ventricular preexcitation in patients with dilated cardiomyopathy and intraventricular conduction delay. Circulation. 2000;101:2703–2709
  9. Amundsen BH, Helle-Valle T, Edvardsen T, Torp H, Crosby J, Ihlen H, et al. Noninvasive myocardial strain measurement by speckle tracking echocardiography: validation against sonomicrometry and tagged magnetic resonance imaging. J Am Coll Cardiol. 2006;47:789–793
  10. Korinek J, Kjaergaard J, Sengupta PP, Yoshifuku S, McMahon EM, Cha SS, et al. High spatial resolution speckle tracking improves accuracy of 2-dimensional strain measurements: an update on a new method in functional echocardiography. J Am Soc Echocardiogr. 2007;20:165–170
  11. Suffoletto MS, Dohi K, Cannesson M, Saba S. Gorcsan J 3rd. Novel speckle-tracking radial strain from routine black-and-white echocardiographic images to quantify dyssynchrony and predict response to cardiac resynchronization therapy. Circulation. 2006;113:960–968
  12. Tops LF, Suffoletto MS, Bleeker GB, Boersma E, vanderWall EE, Gorcsan J, et al. Speckle-tracking radial strain reveals left ventricular dyssynchrony in patients with permanent right ventricular pacing. J Am Coll Cardiol. 2007;50:1180–1188
  13. Gorcsan J, Tanabe M, Bleeker GB, Suffoletto MS, Thomas NC, Saba S, et al. Combined longitudinal and radial dyssynchrony predicts ventricular response after resynchronization therapy. J Am Coll Cardiol. 2007;50:1476–1483
  14. Donal E, Tournoux F, Leclercq C, De Place C, Solnon A, Derumeaux G, et al. Assessment of longitudinal and radial ventricular dyssynchrony in ischemic and nonischemic chronic systolic heart failure: a two-dimensional echocardiographic speckle-tracking strain study. J Am Soc Echocardiogr. 2008;21:58–65
  15. Tanabe M, Lamia B, Tanaka H, Schwartzman D, Pinsky MR. Gorcsan J III. Echocardiographic speckle tracking radial strain imaging to assess ventricular dyssynchrony in a pacing model of resynchronization therapy. J Am Soc Echocardiogr. 2008;21:1382–1388
  16. Auricchio A, Stellbrink C, Block M, Sack S, Vogt J, Bakker P, et al. Effect of pacing chamber and atrioventricular delay on acute systolic function of paced patients with congestive heart failure. The Pacing Therapies for Congestive Heart Failure Study Group. The Guidant Congestive Heart Failure Research Group. Circulation. 1999;99:2993–3001
  17. Leclercq C, Faris O, Tunin R, Johnson J, Kato R, Evans F, et al. Systolic improvement and mechanical resynchronization does not require electrical synchrony in the dilated failing heart with left bundle-branch block. Circulation. 2002;106:1760–1763
  18. Breithardt OA, Stellbrink C, Kramer AP, Sinha AM, Franke A, Salo R, et al. PATH-CHF Study Group. Pacing Therapies for Congestive Heart Failure. Echocardiographic quantification of left ventricular asynchrony predicts an acute hemodynamic benefit of cardiac resynchronization therapy. J Am Coll Cardiol. 2002;40:536–545
  19. Abraham WT, Fisher WG, Smith AL, Delurgio DB, Leon AR, Loh E, et al. MIRACLE Study Group. Multicenter InSync Randomized Clinical Evaluation. Cardiac resynchronization in chronic heart failure. N Engl J Med. 2002;346:1845–1853
  20. Cleland J, Daubert JC, Erdmann E, Freemantle N, Gras D, Kappenberger L, et al. Cardiac Resynchronization-Heart Failure (CARE-HF) Study Investigators. The effect of cardiac resynchronization on morbidity and mortality in heart failure. N Engl J Med. 2005;352:1539–1549
  21. Tournoux FB, Alabiad C, Fan D, Chen AA, Chaput M, Heist EK, et al. Echocardiographic measures of acute haemodynamic response after cardiac resynchronization therapy predict long-term clinical outcome. Eur Heart J. 2007;28:1143–1148
  22. Marcus GM, Rose E, Viloria EM, Schafer J, De Marco T, et al. VENTAK CHF/CONTAK-CD Biventricular Pacing Study Investigators. Septal to posterior wall motion delay fails to predict reverse remodeling or clinical improvement in patients undergoing cardiac resynchronization therapy. J Am Coll Cardiol. 2005;46:2208–2214
  23. Helm RH, Leclercq C, Faris OP, Ozturk C, McVeigh E, Lardo AC, et al. Cardiac dyssynchrony analysis using circumferential versus longitudinal strain: implications for assessing cardiac resynchronization. Circulation. 2005;111:2760–2767
  24. Prinzen FW, Hunter WC, Wyman BT, McVeigh ER. Mapping of regional myocardial strain and work during ventricular pacing: experimental study using magnetic resonance imaging tagging. J Am Coll Cardiol. 1999;33:1735–1742

PII: S0894-7317(09)00389-7

doi: 10.1016/j.echo.2009.04.029

Journal of the American Society of Echocardiography
Volume 22, Issue 7 , Pages 839-846 , July 2009

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