Journal of the American Society of Echocardiography
Volume 22, Issue 12 , Pages 1327-1334 , December 2009

Diastolic Dysfunction and Its Histopathological Correlation in Obstructive Hypertrophic Cardiomyopathy in Children and Adolescents

  • Shaji C. Menon, MD

      Affiliations

    • Department of Pediatric and Adolescent Medicine, Division of Pediatric Cardiology, Mayo Clinic, Rochester, Minnesota
    • Corresponding Author InformationReprint requests: Shaji C. Menon, MD, University of Utah School of Medicine, Division of Pediatric Cardiology, 100 N Mario Capechhi Drive, Salt Lake City, UT 84113.
    • ,
  • Benjamin W. Eidem, MD

      Affiliations

    • Department of Pediatric and Adolescent Medicine, Division of Pediatric Cardiology, Mayo Clinic, Rochester, Minnesota
    • Department of Medicine, Division of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota
    • ,
  • Joseph A. Dearani, MD

      Affiliations

    • Department of Surgery, Division of Cardiothoracic Surgery, Mayo Clinic, Rochester, Minnesota
    • ,
  • Steve R. Ommen, MD

      Affiliations

    • Department of Medicine, Division of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota
    • ,
  • Michael J. Ackerman, MD, PhD

      Affiliations

    • Department of Pediatric and Adolescent Medicine, Division of Pediatric Cardiology, Mayo Clinic, Rochester, Minnesota
    • Department of Medicine, Division of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota
    • ,
  • Dylan Miller, MD

      Affiliations

    • Department of Laboratory Medicine and Pathology, Division of Anatomic Pathology, Mayo Clinic, Rochester, Minnesota

References 

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  14. Tsang TM, Barnes ME, Gersh BJ, Bailey KR, Seward JB. Left atrial volume as a morphophysiologic expression of left ventricular diastolic dysfunction and relation to cardiovascular risk burden. Am J Cardiol. 2002;90:1284–1289
  15. Ren JF, Kotler MN, DePace NL, Mintz GS, Kimbiris D, Kalman P, et al. Two-dimensional echocardiographic determination of left atrial emptying volume: a noninvasive index in quantifying the degree of nonrheumatic mitral regurgitation. J Am Coll Cardiol. 1983;2:729–736
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  17. Lamke GT, Allen RD, Edwards WD, Tazelaar HD, Danielson GK. Surgical pathology of subaortic septal myectomy associated with hypertrophic cardiomyopathy. A study of 204 cases (1996-2000). Cardiovasc Pathol. 2003;12:149–158
  18. Taggart NW, Cetta F, O'Leary PW, Eidem BW. Left atrial volume in children: normative data and impact of increased left ventricular preload in congenital heart disease. [abstract 4563] Circulation. 2008;118:S_911
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  20. Menon SC, Ackerman MJ, Cetta F, O'Leary PW, Eidem BW. Significance of left atrial volume in patients < 20 years of age with hypertrophic cardiomyopathy. Am J Cardiol. 2008;102:1390–1393
  21. Menon SC, Ackerman MJ, Ommen SR, Cabalka AK, Hagler DJ, O'Leary PW, et al. Impact of septal myectomy on left atrial volume and left ventricular diastolic filling patterns: an echocardiographic study of young patients with obstructive hypertrophic cardiomyopathy. J Am Soc Echocardiogr. 2008;21:684–688
  22. Ommen SR, Nishimura RA, Appleton CP, Miller FA, Oh JK, Redfield MM, et al. Clinical utility of Doppler echocardiography and tissue Doppler imaging in the estimation of left ventricular filling pressures: a comparative simultaneous Doppler-catheterization study. Circulation. 2000;102:1788–1794
  23. Mohammed A, Mertens L, Friedberg MK. Relations between systolic and diastolic function in children with dilated and hypertrophic cardiomyopathy as assessed by tissue Doppler imaging. J Am Soc Echocardiogr. 2009;22:145–151
  24. Karlon WJ, McCulloch AD, Covell JW, Hunter JJ, Omens JH. Regional dysfunction correlates with myofiber disarray in transgenic mice with ventricular expression of ras. Am J Physiol Heart Circ Physiol. 2000;278:H898–H906
  25. Popovic ZB, Kwon DH, Mishra M, Buakhamsri A, Greenberg NL, Thamilarasan M, et al. Association between regional ventricular function and myocardial fibrosis in hypertrophic cardiomyopathy assessed by speckle tracking echocardiography and delayed hyperenhancement magnetic resonance imaging. J Am Soc Echocardiogr. 2008;21:1299–1305
  26. Ganame J, Mertens L, Eidem BW, Claus P, D'Hooge J, Havemann LM, et al. Regional myocardial deformation in children with hypertrophic cardiomyopathy: morphological and clinical correlations. Eur Heart J. 2007;28:2886–2894

PII: S0894-7317(09)00766-4

doi: 10.1016/j.echo.2009.08.014

Journal of the American Society of Echocardiography
Volume 22, Issue 12 , Pages 1327-1334 , December 2009

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