Journal of the American Society of Echocardiography
Volume 23, Issue 1 , Pages 79-85 , January 2010

Effect of Acoustic Power on In Vivo Molecular Imaging with Targeted Microbubbles: Implications for Low-Mechanical Index Real-Time Imaging

References 

  1. Kaufmann B, Wei K, Lindner JR. Molecular imaging with targeted contrast ultrasound. Curr Opin Biotech. 2007;18:11–16
  2. Lindner JR, Song J, Christiansen J, Klibanov AL, Xu F, Ley K. Ultrasound assessment of inflammation and renal tissue injury with microbubbles targeted to P-selectin. Circulation. 2001;104:2107–2112
  3. Lindner JR, Song J, Xu F, Klibanov AL, Singbartl K, Ley K, et al. Noninvasive ultrasound imaging of inflammation using microbubbles targeted to activated leukocytes. Circulation. 2000;102:2745–2750
  4. Church CC. The effects of an elastic solid surface layer on the radial pulsations of gas bubbles. J Acoust Soc Am. 1995;97:1510
  5. Khismatullin DB, Nadim A. Radial oscillations of encapsulated microbubbles in viscoelastic liquids. Phys Fluids. 2002;14:3534–3557
  6. de Jong N, Hoff L, Skotland T, Bom N. Absorption and scatter of encapsulated gas filled microspheres: theoretical considerations and some measurements. Ultrasonics. 1992;30:95–103
  7. Zhao S, Kruse DE, Ferrara KW, Dayton PA. Acoustic response from adherent targeted contrast agents. J Acoust Soc Am. 2006;120:EL63–EL69
  8. Lankford M, Behm CZ, Yeh J, Klibanov AL, Robinson P, Lindner JR. Effect of microbubble ligation to cells on ultrasound signal enhancement: implications for targeted imaging. Invest Radiol. 2006;41:721–728
  9. Sasaki M, Ostanin D, Elrod JW, Oshima T, Jordan P, Itoh M, et al. TNF-alpha-induced endothelial cell adhesion molecule expression is cytochrome P-450 monooxygenase dependent. Am J Physiol Cell Physiol. 2003;284:C422–C428
  10. Kaufmann BA, Sanders JM, Davis C, Xie A, Aldred P, Sarembock IJ, et al. Molecular imaging of inflammation in atherosclerosis with targeted ultrasound detection of vascular cell adhesion molecule-1. Circulation. 2007;116:276–284
  11. Dayton PA, Chomas JE, Lum A, Allen J, Lindner JR, Simon SI. Optical and acoustical dynamics of microbubble contrast agents inside neutrophils. Biophys J. 2001;80:1547–1556
  12. van Wamel A, Bouakaz A, Versluis M, de Jong N. Micromanipulation of endothelial cells: ultrasound-microububble-cell interaction. Ultrasound Med Biol. 2004;30:1255–1258

 This study was supported by grants R01-DK063508, R01-HL078610, and R01-HL074443 to Dr Lindner from the National Institutes of Health (Bethesda, MD). Dr Kaufmann is supported by a research grant from the Lichtenstein Foundation (New York, NY), and Dr Carr is supported by a postdoctoral fellowship grant from the American Heart Association (Dallas, TX).

PII: S0894-7317(09)00902-X

doi: 10.1016/j.echo.2009.09.025

Journal of the American Society of Echocardiography
Volume 23, Issue 1 , Pages 79-85 , January 2010

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