Journal of the American Society of Echocardiography
Volume 23, Issue 1 , Pages 95-103 , January 2010

Quantitative Analysis of Function and Perfusion during Dobutamine Stress in the Detection of Coronary Stenoses: Two-Dimensional Strain and Contrast Echocardiography Investigations

  • Patricia Reant, MD

      Affiliations

    • Inserm U828, IFR4, Pessac, France
    • University Bordeaux 2, France
    • C-H-U of Bordeaux, Bordeaux-Pessac, France
    • ,
  • Louis Labrousse, MD

      Affiliations

    • Inserm U828, IFR4, Pessac, France
    • University Bordeaux 2, France
    • C-H-U of Bordeaux, Bordeaux-Pessac, France
    • ,
  • Stephane Lafitte, MD, PhD

      Affiliations

    • Inserm U828, IFR4, Pessac, France
    • University Bordeaux 2, France
    • C-H-U of Bordeaux, Bordeaux-Pessac, France
    • Corresponding Author InformationReprint requests: Stephane Lafitte, MD, PhD, Hopital Cardiologique Haut-Leveque, Avenue de Magellan, 33604 Pessac, France.
    • ,
  • Lilianne Tariosse, Tech

      Affiliations

    • Inserm U828, IFR4, Pessac, France
    • ,
  • Simone Bonoron-Adele, PhD

      Affiliations

    • Inserm U828, IFR4, Pessac, France
    • ,
  • Philippe Padois, PhD

      Affiliations

    • Inserm U828, IFR4, Pessac, France
    • ,
  • Raymond Roudaut, MD

      Affiliations

    • University Bordeaux 2, France
    • C-H-U of Bordeaux, Bordeaux-Pessac, France
    • ,
  • Pierre Dos Santos, MD, PhD

      Affiliations

    • Inserm U828, IFR4, Pessac, France
    • University Bordeaux 2, France
    • C-H-U of Bordeaux, Bordeaux-Pessac, France
    • ,
  • Anthony DeMaria, MD, FACC

      Affiliations

    • University of California at San Diego, California

References 

  1. Picano E, Lattanzi F, Orlandini A, Marini C, L'Abbate A. Stress echocardiography and the human factor: the importance of being expert. J Am Coll Cardiol. 1991;17:666–669
  2. Leong-Poi H, Rim SJ, Le DE, Fisher NG, Wei K, Kaul S. Perfusion versus function: the ischemic cascade in demand ischemia: implications of single-vessel versus multivessel stenosis. Circulation. 2002;105:987–992
  3. Wei K, Jayaweera AR, Firoozan S, Linka A, Skyba DM, Kaul S. Quantification of myocardial blood flow with ultrasound-induced destruction of microbubbles administered as a constant venous infusion. Circulation. 1998;97:473–483
  4. Porter TR, Xie F, Kilzer K, Deligonul U. Detection of myocardial perfusion abnormalities during dobutamine and adenosine stress echocardiography with transient myocardial contrast imaging after minute quantities of intravenous perfluorocarbon-exposed sonicated dextrose albumin. J Am Soc Echocardiogr. 1996;9:779–786
  5. Masugata H, Peters B, Lafitte S, Strachan M, Ohmori K, DeMaria AN. Quantitative assessment of myocardial perfusion during graded coronary stenosis by real-time myocardial contrast echo refilling curves. J Am Coll Cardiol. 2001;37:262–269
  6. Masugata H, Peters B, Lafitte S, Strachan GM, Ohmori K, DeMaria AN. Comparative value of dobutamine and adenosine stress in the detection of coronary stenosis with myocardial contrast echocardiography. Circulation. 2001;103:2724–2730
  7. Toyoda T, Baba H, Akasaka T, Akiyama M, Neishi Y, Tomita J, et al. Assessment of regional myocardial strain by a novel automated tracking system from digital image files. J Am Soc Echocardiogr. 2004;17:1234–1238
  8. Korinek J, Wang J, Sengupta PP, Miyazaki C, Kjaergaard J, McMahon E, et al. Two-dimensional strain—a Doppler-independent ultrasound method for quantitation of regional deformation: validation in vitro and in vivo. J Am Soc Echocardiogr. 2005;18:1247–1253
  9. Langeland S, D'hooge J, Wouters PF, Leather HA, Claus P, Bijnens B, et al. Experimental validation of a new ultrasound method for the simultaneous assessment of radial and longitudinal myocardial deformation independent of insonation angle. Circulation. 2005;112:2157–2162
  10. Amundsen BH, Helle-Valle T, Edvardsen T, Torp H, Crosby J, Lyseggen E, et al. Noninvasive myocardial strain measurement by speckle tracking echocardiography: validation against sonomicrometry and tagged magnetic resonance imaging. J Am Coll Cardiol. 2006;47:789–793
  11. Reant P, Labrousse L, Lafitte S, Bordachar P, Pillois X, Tariosse L, et al. Experimental validation of circumferential, longitudinal and radial 2-dimensional strain during dobutamine stress echocardiography. J Am Coll Cardiol. 2008;51:149–157
  12. Hanekom L, Cho GY, Leano R, Jeffriess L, Marwick TH. Comparison of two-dimensional speckle and tissue Doppler strain measurement during dobutamine stress echocardiography: an angiographic correlation. Eur Heart J. 2007;28:1765–1772
  13. Ingul CB, Stoylen A, Slordahl SA, Wiseth R, Burgess M, Marwick TH. Automated analysis of myocardial deformation at dobutamine stress echocardiography: an angiographic validation. J Am Coll Cardiol. 2007;49:1651–1659
  14. Lafitte S, Masugata H, Peters B, Togni M, Strachan M, Yao B, et al. Accuracy and reproducibility of coronary flow rate assessment by real-time contrast echocardiography: in vitro and in vivo studies. J Am Soc Echocardiogr. 2001;14:1010–1019
  15. Lafitte S, Reant P, Labrousse L, Bordachar P, Tariosse L, Beauvoit B, et al. Effects of right, left, and biventricular pacing on myocardial perfusion in ischemic conditions. J Cardiovasc Electrophysiol. 2006;17:1121–1128
  16. Hanley JA, McNeil BJ. The meaning and use of the area under a receiver operating characteristic (ROC) curve. Radiology. 1982;143:29–36
  17. Hanley JA, McNeil BJ. A method of comparing the areas under receiver operating characteristic curves derived from the same cases. Radiology. 1983;148:839–843
  18. Weidemann F, Dommke C, Bijnens B, Claus P, D'Hooge J, Mertens P, et al. Defining the transmurality of a chronic myocardial infarction by ultrasonic strain rate imaging. Implications for identifying intramural viability. An experimental study. Circulation. 2003;107:883–888
  19. Weidemann F, Jamal F, Sutherland GR, Claus P, Kowalski M, Hatle L, et al. Myocardial function defined by strain rate and strain during alterations in inotropic states and heart rate. Am J Physiol Heart Circ Physiol. 2002;283:H792–H799
  20. Voigt JU, Exner B, Schmiedehausen K, Huchzermeyer C, Reulbach U, Nixdorff U, et al. Strain-rate imaging during dobutamine stress echocardiography provides objective evidence of inducible ischemia. Circulation. 2003;107:2120–2126
  21. Hanekom L, Cho GY, Leano R, Jeffriess L, Marwick TH. Comparison of two-dimensional speckle and tissue Doppler strain measurement during dobutamine stress echocardiography: an angiographic correlation. Eur Heart J. 2007;28:1765–1772
  22. Donal E, Bergerot C, Thibault H, Ernande L, Loufoua J, Augeul L, et al. Influence of afterload on left ventricular radial and longitudinal systolic functions: a two-dimensional strain imaging study. Eur J Echocardiogr. 2009;[Epub ahead of print]
  23. Lafitte S, Perlant M, Reant P, Serri K, Douard H, DeMaria A, et al. Impact of impaired myocardial deformations on exercise tolerance and prognosis in patients with asymptomatic aortic stenosis. Eur J Echocardiogr. 2009;10:414–419
  24. Jones CJ, Raposo L, Gibson DG. Functional importance of the long axis dynamics of the human left ventricle. Br Heart J. 1990;63:215–220
  25. Greenbaum RA, Ho SY, Gibson DG, Becker AE, Anderson RH. Left ventricular fibre architecture in man. Br Heart J. 1981;45:248–263
  26. Chan J, Hanekom L, Wong C, Leano R, Cho JY, Marwick TH. Differentiation of subendocardial and transmural infarction using two-dimensional strain rate imaging to assess short-axis and long-axis myocardial function. J Am Coll Cardiol. 2006;48:2026–2033
  27. Marwick TH, Brunken R, Meland N, Brochet E, Baer FM, Binder T, et al. Accuracy and feasibility of contrast echocardiography for detection of perfusion defects in routine practice: comparison with wall motion and technetium-99m sestamibi single-photon emission computed tomography. The Nycomed NC100100 Investigators. J Am Coll Cardiol. 1998;32:1260–1269
  28. Shimoni S, Zoghbi WA, Xie F, Kricsfeld D, Iskander S, Gobar L, et al. Real-time assessment of myocardial perfusion and wall motion during bicycle and treadmill exercise echocardiography: comparison with single photon emission computed tomography. J Am Coll Cardiol. 2001;37:741–747
  29. Elhendy A, O'Leary EL, Xie F, McGrain AC, Anderson JR, Porter TR. Comparative accuracy of real-time myocardial contrast perfusion imaging and wall motion analysis during dobutamine stress echocardiography for the diagnosis of coronary artery disease. J Am Coll Cardiol. 2004;44:2185–2191
  30. Korosoglou G, Dubart AE, DaSilva KG, Labadze N, Hardt S, Hansen A, et al. Real-time myocardial perfusion imaging for pharmacologic stress testing: added value to single photon emission computed tomography. Am Heart J. 2006;151:131–138
  31. Mor-Avi V, Caiani EG, Collins KA, Korcarz CE, Bednarz JE, Lang RM. Combined assessment of myocardial perfusion and regional left ventricular function by analysis of contrast-enhanced power modulations images. Circulation. 2001;104:352–357
  32. Mor-Avi V, Korcarz CE, Collins KA, Decara JM, Caiani EG, Lang RM. Simultaneous real-time echocardiographic imaging of myocardial perfusion and regional function using color-encoded, contrast-enhanced power modulation. J Am Soc Echocardiogr. 2003;16:1258–1266
  33. Bogaert J, Rademakers FE. Regional nonuniformity of normal adult human left ventricle. Am J Physiol Heart Circ Physiol. 2001;280:H610–H620

 Dr Patricia Reant was supported by the French Federation of Cardiology.

 Conflicts of interest or financial statement to disclose: none.

PII: S0894-7317(09)00906-7

doi: 10.1016/j.echo.2009.10.001

Journal of the American Society of Echocardiography
Volume 23, Issue 1 , Pages 95-103 , January 2010

Article Tools

* Image Usage & Resolution