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Journal of the American Society of Echocardiography
Volume 23, Issue 4
, Pages 343-350
, April 2010
Molecular Imaging of Vascular Phenotype in Cardiovascular Disease: New Diagnostic Opportunities on the Horizon
References
- . On a new kind of rays. Nature. 1896;53:274–276
- . Microbubble persistence in the microcirculation during ischemia/reperfusion and inflammation is caused by integrin- and complement-mediated adherence to activated leukocytes. Circulation. 2000;101:668–675
- Detection of retained microbubbles in carotid arteries with real-time low mechanical index imaging in the setting of endothelial dysfunction. J Am Coll Cardiol. 2004;44:1036–1046
- Noninvasive ultrasound imaging of inflammation using microbubbles targeted to activated leukocytes. Circulation. 2000;102:2745–2750
- . Non-invasive imaging of myocardial reperfusion injury using leukocyte-targeted contrast echocardiography. Circulation. 2002;105:1764–1767
- Leukocyte-targeted myocardial contrast echocardiography can assess the degree of acute allograft rejection in a rat cardiac transplantation model. Circulation. 2004;109:1056–1061
- . The role of complement in the adherence of microbubbles to dysfunctional arterial endothelium and atherosclerotic plaque. Cardiovasc Res. 2007;73:597–606
- . Optical and acoustical observations of the effects of ultrasound on contrast agents. IEEE Trans Ultrason Ferroelect Freq Contr. 1999;46:220–232
- . “Stable” intertial cavitation. Ultrasound Med Biol. 2001;27:1435–1437
- Non-invasive imaging of inflammation by ultrasound detection of phagocytosed microbubbles. Circulation. 2000;102:531–538
- Optical and acoustical dynamics of microbubble contrast agents inside neutrophils. Biophys J. 2001;80:1547–1556
- . Effect of microbubble attachment to cells on ultrasound signal enhancement: implications for targeted imaging. Invest Radiol. 2006;41:721–728
- Effect of acoustic power on in vivo molecular imaging with targeted microbubbles: implications for low mechanical index real-time imaging. J Am Soc Echocardiogr. 2010;23:79–85
- Missed diagnoses of acute cardiac ischemia in the emergency department. N Engl J Med. 2005;342:1163–1170
- . Emergency room triage of patients with acute chest pain by means of rapid testing for cardiac troponin T or troponin I. N Engl J Med. 1997;337:1648–1653
- Regional left ventricular perfusion and function in patients presenting to the emergency department with chest pain and no ST-segment elevation. Eur Heart J. 2005;26:1606–1611
- Metabolic imaging with beta-methyl-p-[(123)I]-iodophenyl-pentadecanoic acid identifies ischemic memory after demand ischemia. Circulation. 2005;112:2169–2174
- . Selectins. J Clin Invest. 1993;91:379–387
- . Changes in P-selectin expression on cardiac microvessels in blood-perfused rat hearts subjected to ischemia reperfusion. Ann Thorac Surg. 2005;79:204–211
- . Ultrasound assessment of inflammation and renal tissue injury with microbubbles targeted to P-selectin. Circulation. 2001;104:2107–2112
- . Detection of recent myocardial ischemia by molecular imaging of P-selectin with targeted contrast echocardiography. Eur Heart J. 2007;28:2011–2017
- Myocardial ischemic memory imaging with molecular echocardiography. Circulation. 2007;115:345–352
- Patterns of vascular cell adhesion molecule-1 and intercellular adhesion molecule-1 expression in rabbit and mouse atherosclerotic lesions and at sites predisposed to lesion formation. Circ Res. 1999;85:199–207
- . Neovascular expression of E-selectin, intercellular adhesion molecule-1, and vascular cell adhesion molecule-1 in human atherosclerosis and their relation to intimal leukocyte content. Circulation. 1996;93:672–682
- Intravascular ultrasound molecular imaging of atheroma components in vivo. J Am Coll Cardiol. 2004;43:453–460
- Molecular imaging of inflammation in atherosclerosis with targeted ultrasound detection of vascular cell adhesion molecule-1. Circulation. 2007;116:276–284
- Molecular imaging of the initial inflammatory response in atherosclerosis: Implications for early detection of disease. Atheroscler Thromb Vasc Biol. 2010;30:54–59
- In vivo molecular imaging of stretch-induced tissue factor in carotid arteries with ligand-targeted nanoparticles. J Am Soc Echocardiogr. 2000;13:608–614
- Molecular imaging of human thrombus with novel abciximab immunobubbles and ultrasound. Stroke. 2007;38:1508–1514
- McCarty OJT, Conley RB, Shentu W, Tormoen GW, Xie A, Qi, Y, et al. Molecular imaging of activated non Willebrand factor to detect high risk atherosclerotic phenotype. J Am Coll Cardiol Img. In Press.
- Endothelial von Willebrand factor recruits platelets to atherosclerosois-prone sites in response to hypercholesterolemia. Blood. 2002;99:4486–4493
- . Non-invasive assessment of angiogenesis by ultrasound and microbubbles targeted to αv-integrins. Circulation. 2003;107:455–460
- Assessment of endogenous and therapeutic arteriogenesis by contrast ultrasound molecular imaging of integrin expression. Circulation. 2005;111:3248–3254
- . Molecular imaging of VCAM-1 and inflammatory cell recruitment during arteriogenesis and vasculogenesis. Circulation. 2008;117:2902–2911
- . Assessment of mechanisms of impaired angiogenesis in diabetes with contrast ultrasound perfusion imaging and molecular imaging of the immune response. J Am Soc Echocardiogr. 2009;22:544
- Molecular profiling of angiogenesis with targeted ultrasound imaging: Early assessment of antiangiogenic therapy effects. Mol Cancer Ther. 2008;7:101–109
- Recombinant antibodies to an oxidized low-density lipoprotein epitope induce rapid regression of atherosclerosis in Apobec-1-/-/low-density lipoprotein receptor-/- mice. J Am Coll Cardiol. 2007;50:2313–2318
- The ATHEROMA (Atorvastatin Therapy: Effects on Reduction of Macrophage Activity) study: evaluation using ultrasmall superparamagnetic iron oxide-enhanced magnetic resonance imaging in carotid disease. J Am Coll Cardiol. 2009;53:2039–2050
Dr. Lindner is supported by grants R01-HL078610, R01-DK063508, and RC01-100659 from the National Institutes of Health (Bethesda, MD).
PII: S0894-7317(10)00097-0
doi: 10.1016/j.echo.2010.01.025
© 2010 American Society of Echocardiography. Published by Elsevier Inc. All rights reserved.
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Journal of the American Society of Echocardiography
Volume 23, Issue 4
, Pages 343-350
, April 2010
