Journal of the American Society of Echocardiography
Volume 23, Issue 7 , Pages 735-740 , July 2010

A Simple Method of Measuring Thoracic Aortic Pulse Wave Velocity in Children: Methods and Normal Values

  • Colleen O. Jo, MD

      Affiliations

    • Division of Pediatric Cardiology, University of Rochester Medical Center, Rochester, New York
    • ,
  • Marc B. Lande, MD

      Affiliations

    • Division of Pediatric Nephrology, University of Rochester Medical Center, Rochester, New York
    • ,
  • Cecilia C. Meagher, MD

      Affiliations

    • Division of Pediatric Cardiology, University of Rochester Medical Center, Rochester, New York
    • ,
  • Hongyue Wang, PhD

      Affiliations

    • Department of Biostatistics and Computational Biology, University of Rochester Medical Center, Rochester, New York
    • ,
  • Roger P. Vermilion, MD

      Affiliations

    • Division of Pediatric Cardiology, University of Rochester Medical Center, Rochester, New York
    • Corresponding Author InformationReprint requests: Roger P. Vermilion, MD, University of Rochester Medical Center, Division of Pediatric Cardiology, 601 Elmwood Avenue, Box 631, Rochester, NY 14642.

References 

  1. Meaume S, Benetos A, Henry OF, Rudnichi A, Safar ME. Aortic pulse wave velocity predicts cardiovascular mortality in subjects >70 years of age. Arterioscler Thromb Vasc Biol. 2001;21:2046–2050
  2. Aggoun Y, Szezepanski I, Bonnet D. Noninvasive assessment of arterial stiffness and risk of atherosclerosic events in children. Pediatr Res. 2005;58:173–178
  3. Safar ME. Systolic blood pressure, pulse pressure and arterial stiffness as cardiovascular risk factors. Curr Opin Nephrol Hypertens. 2001;10:257–261
  4. Blacher J, Guérin AP, Pannier B, Marchais SJ, Safar ME, London GM. Impact of aortic stiffness on survival in end-stage renal disease. Circulation. 1999;99:2434–2439
  5. Pannier B, Guérin AP, Marchais SJ, Safar ME, London GM. Stiffness of capacitive and conduit arteries: prognostic significance for end-stage renal disease patients. Hypertension. 2005;45:592–596
  6. Blacher J, Asmar R, Djane S, London G, Safar ME. Aortic pulse wave velocity as a marker of cardiovascular risk in hypertensive patients. Hypertension. 1999;33:1111–1117
  7. Blacher J, Safar ME, Guérin AP, Pannier P, Marchais SJ, London GM. Aortic pulse wave velocity index and mortality in end-stage renal disease. Kidney Int. 2003;63:1852–1860
  8. Patrianakos AP, Karakitsos DN, de Groot E, Parthenakis IF, Daphnis EK, Vardas PE. Alteration of proximal aorta biophysical properties in patients with end stage renal disease. Heart. 2006;92:228–232
  9. Ou P, Celermajer DS, Jolivet O, Buyens F, Herment A, Sidi D, et al. Increased central aortic stiffness and left ventricular mass in normotensive young subjects after coarctation repair. Am Heart J. 2008;155:187–193
  10. Ou P, Celermajer DS, Raisky O, Jolivet O, Buyens F, Herment A, et al. Angular (Gothic) aortic arch leads to enhanced systolic wave reflection, central aortic stiffness, and increase left ventricular mass late after aortic coarctation repair: evaluation with magnetic resonance flow mapping. J Thorac Cardiovasc Surg. 2008;135:62–68
  11. Senzaki H, Iwamoto Y, Ishido H, Matsunaga T, Taketazu M, Kobayashi T, et al. Arterial haemodynamics in patients after repair of tetralogy of Fallot: influence on left ventricular afterload and aortic dilatation. Heart. 2008;94:70–74
  12. Cheung YF, Ou X, Wong SJ. Central and peripheral arterial stiffness in patients after surgical repair of tetralogy of Fallot: implications for aortic root dilatation. Heart. 2006;92:1827–1830
  13. Groenink M, deRoos A, Mulder BJ, Spaam JA, van der Wall EE. Changes in aortic distensibility and pulse wave velocity assessed with magnetic resonance imaging following beta-blocker therapy in Marfans syndrome. Am J Cardiol. 1998;82:203–208
  14. Stary HC. Evolution and progression of atherosclerotic lesions in coronary arteries of children and young adults. Arteriosclerosis. 1989;9:I19–I32
  15. McGill HC. Persistent problems in the pathogenesis of atherosclerosis. Arteriosclerosis. 1984;4:443–451
  16. Sakuragi S, Abhayaratna K, Gravenmaker KJ, O'Reilly C, Srikusalallukul W, Budge MM, et al. Influence of adiposity and physical activity on arterial stiffness in healthy children. Hypertension. 2009;53:611–616
  17. Schack-Nielsen L, Mølgaard C, Larsen D, Martyn C, Michaelsen K. Arterial stiffness in 10-year-old children: current and early determinants. Br J Nutr. 2005;94:1004–1011
  18. Stakos DA, Schuster DP, Sparks EA, Wooley CF, Osei K, Boudoulas H. Cardiovascular effects of type 1 diabetes mellitus in children. Angiology. 2005;56:311–317
  19. Baguet JP, Douchin S, Pierre H, Rossignol AM, Bost M, Mallion JM. Structural and functional abnormalities of large arteries in Turner syndrome. Heart. 2005;91:1442–1446
  20. Ooyanagi R, Fuse S, Tomita H, Takamuro M, Horita N, Mori M, et al. Pulse wave velocity and ankle brachial index in patients with Kawasaki disease. Pediatr Int. 2004;46:398–402
  21. Laurent S, Cockcroft J, Van Bortel L, Boutouyrie P, Giannattasio C, Hayoz D, et al. Expert consensus document on arterial stiffness: methodological issues and clinical applications. Eur Heart J. 2006;27:2588–2605
  22. Rogers WJ, Hu YL, Coast D, Vido DA, Kramer CM, Pyeritz RE, et al. Age-associated changes in regional aortic pulse wave velocity. J Am Coll Cardiol. 2001;38:1123–1129
  23. Patrianakos AP, Fragiskos IP, Karakitsos D, DeGroot E, Skalidis EA, Nyktari E. Relation of proximal aorta stiffness to left ventricular diastolic function in patients with end-stage renal disease. J Am Soc Echocardiogr. 2007;20:314–323
  24. Sandor GG, Hishitani T, Petty RE, Potts MT, DeSouza A, DeSouza E, et al. A novel Doppler echocardiographic method of measuring the biophysical properties of the aorta in pediatric patients. J Am Soc Echocardiogr. 2003;16:745–750
  25. Latham RD, Westerhof N, Sipkema R, Rubal BJ, Reuderink P, Murgo JP. Regional wave travel and reflections along the human aorta: a study with six simultaneous micromanometric pressures. Circulation. 1985;72:1257–1269
  26. O'Rourke MF, Staessen JA, Vlachopoulos C, Duprez D, Plante GE. Clinical applications of arterial stiffness; definitions and reference values. Am J Hypertens. 2002;15:426–444
  27. Nichols WW, O'Rourke MF. 5th ed.. McDonald's blood flow in arteries: theoretical, experimental and clinical principles. 58. London: Hodder Arnold; 2005;270-2
  28. Mohiaddin RH, Firmin DN, Longmore DB. Age-related changes of human aortic flow wave velocity measured noninvasively by magnetic resonance imaging. J Appl Physiol. 1993;74:492–497
  29. Hamilton PK, Lockhart CJ, Quinn CE, McVeigh GE. Arterial stiffness: clinical relevance, measurement and treatment. Clin Sci. 2007;113:157–170
  30. Zambanini A, Cunningham SL, Parker KH, Khir AW, McG Thom SA, Hughes AS. Wave-energy patterns in carotid, brachial, and radial arteries: a noninvasive approach using wave-intensity analysis. Am J Physiol Heart Circ Physiol. 2005;289:H270–H276
  31. Khoshdel AR, Thakkinstian A, Carney SL, Attia J. Estimation of an age-specific reference interval for pulse wave velocity: a meta-analysis. J Hypertens. 2006;24:1231–1237
  32. Vlachopoulos C, Dima I, Aznaouridis K, Vasiliadou C, Ioakeimidis N, Aggeli C, et al. Acute systemic inflammation increases arterial stiffness and decreases wave reflection in healthy individuals. Circulation. 2005;112:2193–2200
  33. Senzaki H, Akagi M, Hishi T, Ishizawa A, Yanagisawa M, Masutani S, et al. Age-associated changes in arterial elastic properties in children. Eur J Pediatr. 2002;161:547–551
  34. Avolio AP, Chen SG, Wang RP, Zhang CL, Li MF, O'Rourke MF. Effects of aging on changing arterial compliance and left ventricular load in a northern Chinese urban community. Circulation. 1983;68:50–58
  35. McEnierny CM, Yasmin , Hall IR, Qasem A, Wilkinson IB, Cockcroft JR, et al. Normal vascular aging: differential effects on wave reflection and aortic pulse wave velocity: the Anglo-Cardiff Collaborative Trial (ACCT). J Am Coll Cardiol. 2005;46:1753–1760
  36. Apter JT, Rabinowitz M, Cummings D. Correlation of viscero-elastic properties of large arteries with microscopic structure. Circ Res. 1966;19:104–121

PII: S0894-7317(10)00356-1

doi: 10.1016/j.echo.2010.04.018

Journal of the American Society of Echocardiography
Volume 23, Issue 7 , Pages 735-740 , July 2010

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