Journal of the American Society of Echocardiography
Volume 23, Issue 8 , Pages 816-822 , August 2010

Low Cardiovascular Risk Is Associated with Favorable Left Ventricular Mass, Left Ventricular Relative Wall Thickness, and Left Atrial Size: The CARDIA Study

  • Samuel S. Gidding, MD

      Affiliations

    • Nemours Cardiac Center, A. I. duPont Hospital for Children, Wilmington, Delaware
    • Corresponding Author InformationReprint requests: Samuel S. Gidding, MD, Nemours Cardiac Center, 1600 Rockland Road, Wilmington, DE 19803.
  • ,
  • Mercedes R. Carnethon, PhD

      Affiliations

    • Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois
  • ,
  • Stephen Daniels, MD, PhD

      Affiliations

    • Department of Pediatrics, University of Colorado School of Medicine, Denver, Colorado
  • ,
  • Kiang Liu, PhD

      Affiliations

    • Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois
  • ,
  • David R. Jacobs Jr., PhD

      Affiliations

    • Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis, Minnesota
  • ,
  • Steve Sidney, MD, MPH

      Affiliations

    • Kaiser-Permanente Division of Research, Oakland California
  • ,
  • Julius Gardin, MD

      Affiliations

    • Department of Internal Medicine, Hackensack University Hospital, Hackensack, New Jersey

References 

  1. Levy D, Garrison RJ, Savage DD, Kannel WB, Castelli WP. Prognostic implications of echocardiographically determined left ventricular mass in the Framingham Heart Study. N Engl J Med. 1990;322:1561–1566
  2. Kizer JR, Bella JN, Palmieri V, Liu JE, Best LG, Lee ET, et al. Left atrial diameter as an independent predictor of first clinical cardiovascular events in middle-aged and elderly adults: the Strong Heart Study (SHS). Am Heart J. 2006;151:412–418
  3. Laukkanen JA, Kurl S, Eranen J, Huttunen M, Salonen JT. Left atrium size and the risk of cardiovascular death in middle-aged men. Arch Intern Med. 2005;165:1788–1793
  4. Devereux RB, Wachtell K, Gerdts E, Boman K, Nieminen MS, Papademetriou V, et al. Prognostic significance of left ventricular mass change during treatment of hypertension. JAMA. 2004;292:2350–2356
  5. Eguchi K, Ishikawa J, Hoshide S, Ishikawa S, Pickering TG, Schwartz JE, et al. Differential impact of left ventricular mass and relative wall thickness on cardiovascular prognosis in diabetic and nondiabetic hypertensive subjects. Am Heart J. 2007;154:79;e9-15
  6. Benjamin EJ, D'Agostino RB, Belanger AJ, Wolf PA, Levy D. Left atrial size and the risk of stroke and death. The Framingham Heart Study. Circulation. 1995;92:835–841
  7. Abhayaratna WP, Seward JB, Appleton CP, Douglas PS, Oh JK, Tajik AJ, et al. Left atrial size: physiologic determinants and clinical applications. J Am Coll Cardiol. 2006;47:2357–2363
  8. Daniels SR, Loggie JM, Khoury P, Kimball TR. Left ventricular geometry and severe left ventricular hypertrophy in children and adolescents with essential hypertension. Circulation. 1998;97:1907–1911
  9. Gardin JM, Wagenknecht LE, Anton-Culver H, Flack J, Gidding S, Kurosaki T, et al. Relationship of cardiovascular risk factors to echocardiographic left ventricular mass in healthy young black and white adult men and women. The CARDIA study. Circulation. 1995;92:380–387
  10. Daniels SR, Witt SA, Glascock B, Khoury PR, Kimball TR. Left atrial size in children with hypertension: the influence of obesity, blood pressure, and left ventricular mass. J Pediatr. 2002;141:186–190
  11. Lorber R, Gidding SS, Daviglus ML, Colangelo LA, Liu K, Gardin JM. Influence of systolic blood pressure and body mass index on left ventricular structure in healthy African-American and white young adults: the CARDIA study. J Am Coll Cardiol. 2003;41:955–960
  12. Gardin JM, Brunner D, Schreiner PJ, Xie X, Reid CL, Ruth K, et al. Demographics and correlates of five-year change in echocardiographic left ventricular mass in young black and white adult men and women: the Coronary Artery Risk Development in Young Adults (CARDIA) study. J Am Coll Cardiol. 2002;40:529–535
  13. Urbina EM, Gidding SS, Bao W, Pickoff AS, Berdusis K, Berenson GS. Effect of body size, ponderosity, and blood pressure on left ventricular growth in children and young adults in the Bogalusa Heart Study. Circulation. 1995;91:2400–2406
  14. Chinali M, Devereux RB, Howard BV, Roman MJ, Bella JN, Liu JE, et al. Comparison of cardiac structure and function in American Indians with and without the metabolic syndrome (the Strong Heart Study). Am J Cardiol. 2004;93:40–44
  15. Fox ER, Taylor J, Taylor H, Han H, Samdarshi T, Arnett D, et al. Left ventricular geometric patterns in the Jackson cohort of the Atherosclerotic Risk in Communities (ARIC) study: clinical correlates and influences on systolic and diastolic dysfunction. Am Heart J. 2007;153:238–244
  16. Stewart KJ, Ouyang P, Bacher AC, Lima S, Shapiro EP. Exercise effects on cardiac size and left ventricular diastolic function: relationships to changes in fitness, fatness, blood pressure and insulin resistance. Heart. 2006;92:893–898
  17. Whalley GA, Doughty RN, Gamble GD, Oxenham HC, Walsh HJ, Reid IR, et al. Association of fat-free mass and training status with left ventricular size and mass in endurance-trained athletes. J Am Coll Cardiol. 2004;44:892–896
  18. Daviglus ML, Stamler J, Pirzada A, Yan LL, Garside DB, Liu K, et al. Favorable cardiovascular risk profile in young women and long-term risk of cardiovascular and all-cause mortality. JAMA. 2004;292:1588–1592
  19. Friedman GD, Cutter GR, Donahue RP, Hughes GH, Hulley SB, Jacobs DR, et al. CARDIA: study design, recruitment, and some characteristics of the examined subjects. J Clin Epidemiol. 1988;41:1105–1116
  20. Sahn DJ, DeMaria A, Kisslo J, Weyman A. Recommendations regarding quantitation in M-mode echocardiography: results of a survey of echocardiographic measurements. Circulation. 1978;58:1072–1083
  21. Jacobs DR, Hahn LP, Haskell WL, Pirie P, Sidney S. Validity and reliability of short physical activity history: CARDIA and the Minnesota Heart Health Program. J Cardiopulm Rehabil. 1989;9:448–459
  22. Sidney S, Haskell WL, Crow R, Sternfeld B, Oberman A, Armstrong MA, et al. Symptom-limited graded treadmill exercise testing in young adults in the CARDIA study. Med Sci Sports Exerc. 1992;24:177–183
  23. Sidney S, Sternfeld B, Haskell WL, Quesenberry CP, Crow RS, Thomas RJ. Seven-year change in graded exercise treadmill test performance in young adults in the CARDIA study. Med Sci Sports Exerc. 1998;30:427–433
  24. de Simone G, Devereux RB, Daniels SR, Koren MJ, Meyer RA, Laragh JH. Effect of growth on variability of left ventricular mass: assessment of allometric signals in adults and children and their capacity to predict cardiovascular risk. J Am Coll Cardiol. 1995;25:1056–1062
  25. Reichek N, Devereux RB. Reliable estimation of peak left ventricular systolic pressure by M-mode echographic-determined end-diastolic relative wall thickness: identification of severe valvular aortic stenosis in adult patients. Am Heart J. 1982;103:202–203
  26. Fox E, Taylor H, Andrew M, Han H, Mohamed E, Garrison R, et al. Body mass index and blood pressure influences on left ventricular mass and geometry in African Americans: the Atherosclerotic Risk in Communities (ARIC) study. Hypertension. 2004;44:55–60
  27. Koren MJ, Mensah GA, Blake J, Laragh JH, Devereux RB. Comparison of left ventricular mass and geometry in black and white patients with essential hypertension. Am J Hypertens. 1993;6:815–823
  28. Olutade BO, Gbadebo TD, Porter VD, Wilkening B, Hall WD. Racial differences in ambulatory blood pressure and echocardiographic left ventricular geometry. Am J Med Sci. 1998;315:101–109
  29. Cuspidi C, Meani S, Fusi V, Valerio C, Catini E, Sala C, et al. Prevalence and correlates of left atrial enlargement in essential hypertension: role of ventricular geometry and the metabolic syndrome: the Evaluation of Target Organ Damage in Hypertension study. J Hypertens. 2005;23:875–882
  30. Vaziri SM, Larson MG, Lauer MS, Benjamin EJ, Levy D. Influence of blood pressure on left atrial size. The Framingham Heart Study. Hypertension. 1995;25:1155–1160
  31. Goette A, Lendeckel U, Kuchenbecker A, Bukowska A, Peters B, Klein HU, et al. Cigarette smoking induces atrial fibrosis in humans via nicotine. Heart. 2007;93:1056–1063
  32. Gidding SS, McMahan CA, McGill HC, Colangelo LA, Schreiner PJ, Williams OD, et al. Prediction of coronary artery calcium in young adults using the Pathobiological Determinants of Atherosclerosis in Youth (PDAY) risk score: the CARDIA study. Arch Intern Med. 2006;166:2341–2347
  33. McGill HC, McMahan CA, Gidding S. Preventing heart disease in the 21st century: Implications of the Pathobiological Determinants of Atherosclerosis in Youth (PDAY) study. Circulation. 2008;117:1216–1227

 Work on this report was supported (or partially supported) by contracts University of Alabama at Birmingham, Coordinating Center, N01-HC-95095 University of Alabama at Birmingham, Field Center, N01-HC-48047 University of Minnesota, Field Center, N01-HC-48048 Northwestern University, Field Center, N01-HC-48049 Kaiser Foundation Research Institute, and N01-HC-48050 University of California, Irvine, Echocardiography Reading Center.

PII: S0894-7317(10)00460-8

doi: 10.1016/j.echo.2010.05.023

Journal of the American Society of Echocardiography
Volume 23, Issue 8 , Pages 816-822 , August 2010